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Isotonitazene is a benzimidazole derived opioid analgesic drug related to etonitazene,[2][3][4] which has been sold as a designer drug.[5][6] It has only around half the potency of etonitazene in animal studies,[2][7][8][9][10][11][12] but it is likely less potent in humans as was seen with etonitazene (1000 times as potent as morphine in animal models yet only 60 times as potent in humans).[2] Isotonitazene (obtained from an online vendor) was fully characterized in November 2019 in a paper where the authors performed a full analytical structure elucidation in addition to determination of the potency at the μ-opioid receptor using a biological functional assay in vitro. While isotonitazene was not compared directly to morphine in this assay, it was found to be around 2.5 times more potent than hydromorphone and slightly more potent than fentanyl